Africa, con su población indígena y sus numerosos países, y una nutrida presenica cristiana y católica, ofrece grandes perspectivas en el campo cultural. El variopinto continente con una población joven, que ama la danza y la música, expresiones espontáneas de la fe, es alberga también la comunidad cristiana que crece más rápidamente. El continente se abre a tendencias globalizadoras, que a veces entran en colisión con la visión tradicional y provocan un aumento de las desigualdades. La evangelización de las culturas, el diálogo intercultural y la inculturación de la fe son espacios válidos para trabajar.

El Departamento África desarrolla las siguientes actividades:

1. A close collaboration with the different departments within the Dicastery for study and research on the cultural situations in particular areas.  
2. Working in collaboration with other Dicasteries specially the Propaganda Fide, and the Council for Inter-religious Dialogue  in the field of Evangelization of Cultures, Inculturation of the Faith and intercultural dialogue.
3. Working with National Episcopal Conferences and the Federations of Episcopal Conferences like SECAM
4. Working with individual Bishops wherever possible and encouraging and participating in national level meetings on subjects in the Cultural field.
5. Cultivating and promoting Catholic Cultures Centres.
6. Holding Continental meetings of the Members, and Consultors of the Dicastery and Presidents of Episcopal Commissions for Culture for galvanising the members, as well as for promoting the Dicastery activities. 
7. Working with Non-Governmental Organisations in the cultural field.
8. Cooperation with Ambassadors.
9. Interaction with Journalists and Associations in Europe who are interested in Africa.
   
10. Identifying local journals and magazines and offer them material for publication.